i don't think you should be thinking topics - to me you should be thinking - what has it been made for - who will it hepl the most - who are my target audience - what are the topics i will be blogging about to help my audience - ony if you help people will they help you in return- by giving you 'value vouchers' as dj demarco calls dollars.
your audience doesn't care whether you are in the weight loss or health and wellness niche - all they care about is ' whats in it for me' how can it help me- and is it easy?
good luck
phil

I think they could go hand in hand. Like health and wellness could feature weight loss, or vice versa. They are both very broad, so you likely wouldn't run out of content ideas. Some might say health and wellness is kind of broad, but you can always narrow your focus as you go through the process of buildling out your website. Sorry to "not answer" your question. Lol I think they are both great ideas.

Hello! I think both of those niches are popular. Weight loss pairs nicely with Health & Wellness.. If you are just focused on weight loss, then I would stick with that. If it's overall health & wellness, I would choose that one.